The progress and promise of RNA medicine─ an arsenal of targeted treatments

JM Sasso, BJB Ambrose, R Tenchov… - Journal of medicinal …, 2022 - ACS Publications
In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

[HTML][HTML] MicroRNAs in neuroinflammation: implications in disease pathogenesis, biomarker discovery and therapeutic applications

JA Slota, SA Booth - Non-coding RNA, 2019 - mdpi.com
The central nervous system can respond to threat via the induction of an inflammatory
response. Under normal circumstances this response is tightly controlled, however …

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19

H Tang, Y Gao, Z Li, Y Miao, Z Huang… - Clinical and …, 2020 - Wiley Online Library
Background COVID‐19 is currently a global pandemic, but the response of human immune
system to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection …

miEAA 2.0: integrating multi-species microRNA enrichment analysis and workflow management systems

F Kern, T Fehlmann, J Solomon, L Schwed… - Nucleic acids …, 2020 - academic.oup.com
Gene set enrichment analysis has become one of the most frequently used applications in
molecular biology research. Originally developed for gene sets, the same statistical …

[HTML][HTML] miRNAs as biomarkers for early cancer detection and their application in the development of new diagnostic tools

LJ Galvão-Lima, AHF Morais, RAM Valentim… - Biomedical engineering …, 2021 - Springer
Over the last decades, microRNAs (miRNAs) have emerged as important molecules
associated with the regulation of gene expression in humans and other organisms …

[HTML][HTML] MiRNAs and cancer: key link in diagnosis and therapy

Y Shi, Z Liu, Q Lin, Q Luo, Y Cen, J Li, X Fang, C Gong - Genes, 2021 - mdpi.com
Since the discovery of the first microRNA (miRNA), the exploration of miRNA biology has
come to a new era in recent decades. Monumental studies have proven that miRNAs can be …

Recent trends in targeting miRNAs for cancer therapy

V Shah, J Shah - Journal of Pharmacy and Pharmacology, 2020 - academic.oup.com
Objectives MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells
for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the …

[HTML][HTML] Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors

Y Duo, Z Xiang, G Gao, G Luo, BZ Tang - TrAC Trends in Analytical …, 2023 - Elsevier
Fluorescent biosensors are powerful analytical tools that have been widely employed in a
range of in vitro and in vivo biomedical applications. However, traditional fluorophores …

The exosome encapsulated microRNAs as circulating diagnostic marker for hepatocellular carcinoma with low alpha‐fetoprotein

S Ghosh, S Bhowmik, S Majumdar… - … journal of cancer, 2020 - Wiley Online Library
Diagnosis of hepatocellular carcinoma (HCC) remains challenging to clinicians, particularly
in a patient with low alpha‐fetoprotein. Here, in silico, ex vivo and in vitro data were …

A programmable DNAzyme for the sensitive detection of nucleic acids

C Shi, D Yang, X Ma, L Pan, Y Shao… - Angewandte Chemie …, 2024 - Wiley Online Library
Nucleic acids in biofluids are emerging biomarkers for the molecular diagnostics of
diseases, but their clinical use has been hindered by the lack of sensitive detection assays …