KIR and HLA under pressure: evidences of coevolution across worldwide populations

DG Augusto, ML Petzl-Erler - Human genetics, 2015 - Springer
KIR (killer cell immunoglobulin-like receptors) and HLA (human leukocyte antigens) are two
distinct gene families with remarkable importance for human immune responses. The …

The Impact of KIR Polymorphism on the Risk of Developing Cancer: Not as Strong as Imagined?

DG Augusto - Frontiers in genetics, 2016 - frontiersin.org
The polymorphism of killer cell immunoglobulin-like receptors (KIR) has been associated
with several diseases, including infection, autoimmunity and cancer. KIR molecules are a …

High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity

LM Amorim, DG Augusto, N Nemat-Gorgani… - Frontiers in …, 2021 - frontiersin.org
The KIR (killer-cell immunoglobulin-like receptor) region is characterized by structural
variation and high sequence similarity among genes, imposing technical difficulties for …

Killer-Cell immunoglobulin-like receptor diversity in an admixed South American population

M Castrillon, ND Marin, AJ Karduss-Urueta… - Cells, 2022 - mdpi.com
Natural Killer (NK) cells are innate immune cells that mediate antiviral and antitumor
responses. NK cell activation and induction of effector functions are tightly regulated by the …

Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (IGHG) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene …

V Calonga-Solís, D Malheiros, MH Beltrame… - Frontiers in …, 2019 - frontiersin.org
Even though immunoglobulins are critical for immune responses and human survival, the
diversity of the immunoglobulin heavy chain gene (IGH) is poorly known and mostly …

Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region

L de Brito Vargas, MH Beltrame, B Ho… - Molecular biology …, 2022 - academic.oup.com
The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen
(HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells …

Differing Evolutionary Histories of the ACTN3*R577X Polymorphism among the Major Human Geographic Groups

CEG Amorim, V Acuna-Alonzo, FM Salzano… - PloS one, 2015 - journals.plos.org
It has been proposed that the functional ACTN3* R577X polymorphism might have evolved
due to selection in Eurasian human populations. To test this possibility we surveyed all …

Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations

LB Vargas, RM Dourado, LM Amorim, B Ho… - Frontiers in …, 2020 - frontiersin.org
Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors
(KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands …

Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop

MK Misra, DG Augusto, GM Martin, N Nemat-Gorgani… - Human immunology, 2018 - Elsevier
The goals of the KIR component of the 17th International HLA and Immunogenetics
Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at …

Fluctuating and Geographically Specific Selection Characterize Rapid Evolution of the Human KIR Region

DG Augusto, PJ Norman, R Dandekar… - Frontiers in …, 2019 - frontiersin.org
The killer-cell immunoglobulin-like receptor (KIR) region comprises a fast-evolving family of
genes that encode receptors for natural killer (NK) cells and have crucial role in host …