Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017 - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Enamel biomimetics—fiction or future of dentistry

M Pandya, TGH Diekwisch - International journal of oral science, 2019 - nature.com
Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals
configured into decussating enamel rods. In recent years, multiple approaches have been …

[HTML][HTML] Protein-mediated enamel mineralization

J Moradian-Oldak - Frontiers in bioscience: a journal and virtual …, 2012 - ncbi.nlm.nih.gov
Enamel is a hard nanocomposite bioceramic with significant resilience that protects the
mammalian tooth from external physical and chemical damages. The remarkable …

Regulation of dental enamel shape and hardness

JP Simmer, P Papagerakis, CE Smith… - Journal of dental …, 2010 - journals.sagepub.com
Epithelial-mesenchymal interactions guide tooth development through its early stages and
establish the morphology of the dentin surface upon which enamel will be deposited …

A post-classical theory of enamel biomineralization… and why we need one

JP Simmer, AS Richardson, YY Hu, CE Smith… - International Journal of …, 2012 - nature.com
Enamel crystals are unique in shape, orientation and organization. They are hundreds of
thousands times longer than they are wide, run parallel to each other, are oriented with …

The circadian clock in enamel development

K Wu, X Li, Y Bai, BC Heng, X Zhang… - International Journal of …, 2024 - nature.com
Circadian rhythms are self-sustaining oscillations within biological systems that play key
roles in a diverse multitude of physiological processes. The circadian clock mechanisms in …

Enamel mineralization and compositional time-resolution in human teeth evaluated via histologically-defined LA-ICPMS profiles

W Müller, A Nava, D Evans, PF Rossi, KW Alt… - … et Cosmochimica Acta, 2019 - Elsevier
Mammalian dental enamel is a key archive for the reconstruction of past environments.
Sequentially mineralizing enamel provides continuous, several year-long records, which …

The circadian clock modulates enamel development

RS Lacruz, JG Hacia, TG Bromage… - Journal of …, 2012 - journals.sagepub.com
Fully mature enamel is about 98% mineral by weight. While mineral crystals appear very
early during its formative phase, the newly secreted enamel is a soft gel-like matrix …

Identification of novel candidate genes involved in mineralization of dental enamel by genome‐wide transcript profiling

RS Lacruz, CE Smith, P Bringas Jr… - Journal of cellular …, 2012 - Wiley Online Library
The gene repertoire regulating vertebrate biomineralization is poorly understood. Dental
enamel, the most highly mineralized tissue in mammals, differs from other calcifying systems …

Mutations in the pH-sensing G-protein-coupled receptor GPR68 cause amelogenesis imperfecta

DA Parry, CEL Smith, W El-Sayed, JA Poulter… - The American Journal of …, 2016 - cell.com
Amelogenesis is the process of dental enamel formation, leading to the deposition of the
hardest tissue in the human body. This process requires the intricate regulation of ion …