Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Cancer is a major medical problem worldwide. Due to its high heterogeneity, the use of the
same drugs or surgical methods in patients with the same tumor may have different curative …

Poor infiltration of T lymphocytes has been regarded as a crucial mechanism of tumor
immune escape. Here, we demonstrate a protective role of KRT17 in colorectal cancer …

Mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) represents a
distinct phenotype among solid tumors characterized by frequent frameshift mutations …

Immune checkpoint inhibitors (ICIs) are effective for various types of cancer, and their
application has led to paradigm shifts in cancer treatment. While many patients can obtain …

Background Identifying biomarkers to predict immune checkpoint inhibitor (ICI) efficacy is
warranted. Considering that somatic mutation-derived neoantigens induce strong immune …

Simple Summary Colorectal cancer is a major health concern globally, and finding ways to
improve treatment outcomes is crucial. This review explores the role of biomarkers …

Immune checkpoint inhibitors (ICIs) have contributed significantly to the treatment of various
types of cancer, including skin cancer. However, not all patients respond; some patients do …

Immunotherapy shows efficacy for multiple cancer types and potential for expanded use.
However, current immune checkpoint inhibitors (ICIs) are ineffective against microsatellite …

Background Intratumor heterogeneity (ITH) in microsatellite instability-high (MSI-H)
colorectal cancer (CRC) has been poorly studied. We aimed to clarify how the ITH of MSI-H …