Biosynthesis and function of chondroitin sulfate

T Mikami, H Kitagawa - Biochimica et Biophysica Acta (BBA)-General …, 2013 - Elsevier
Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …

The molecular diversity of glycosaminoglycans shapes animal development

HE Bülow, O Hobert - Annu. Rev. Cell Dev. Biol., 2006 - annualreviews.org
Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked
to a protein core, are components of the extracellular matrix of all multicellular organisms …

Vitamin C–squalene bioconjugate promotes epidermal thickening and collagen production in human skin

R Gref, C Deloménie, A Maksimenko, E Gouadon… - Scientific reports, 2020 - nature.com
Abstract Vitamin C (Vit C) benefits to human skin physiology notably by stimulating the
biosynthesis of collagen. The main cutaneous collagens are types I and III, which are less …

The GAGOme: a cell-based library of displayed glycosaminoglycans

YH Chen, Y Narimatsu, TM Clausen, C Gomes… - Nature …, 2018 - nature.com
Glycosaminoglycans (GAGs) are essential polysaccharides in normal physiology and
disease. However, understanding of the contribution of specific GAG structures to specific …

“GAG-ing with the neuron”: the role of glycosaminoglycan patterning in the central nervous system

PD Smith, VJ Coulson-Thomas, S Foscarin… - Experimental …, 2015 - Elsevier
Proteoglycans (PGs) are a diverse family of proteins that consist of one or more
glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major …

Biological functions of iduronic acid in chondroitin/dermatan sulfate

MA Thelin, B Bartolini, J Axelsson… - The FEBS …, 2013 - Wiley Online Library
The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the
polysaccharides because it generates a more flexible chain with increased binding …

[HTML][HTML] The echinoderm adhesome

CA Whittaker, KF Bergeron, J Whittle… - Developmental …, 2006 - Elsevier
Although the development of sea urchin embryos has been studied extensively and clearly
involves both cell adhesion and cell migration, rather little is known about the adhesion …

An Overview of in vivo Functions of Chondroitin Sulfate and Dermatan Sulfate Revealed by Their Deficient Mice

S Mizumoto, S Yamada - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently
attached to specific core proteins to form proteoglycans in their biosynthetic pathways. They …

The specific role of dermatan sulfate as an instructive glycosaminoglycan in tissue development

S Mizumoto, S Yamada - International Journal of Molecular Sciences, 2022 - mdpi.com
The crucial roles of dermatan sulfate (DS) have been demonstrated in tissue development of
the cutis, blood vessels, and bone through construction of the extracellular matrix and cell …

Musculocontractural Ehlers‐Danlos Syndrome (former EDS type VIB) and adducted thumb clubfoot syndrome (ATCS) represent a single clinical entity caused by …

F Malfait, D Syx, P Vlummens, S Symoens… - Human …, 2010 - Wiley Online Library
We present clinical and molecular findings of three patients with an EDS VIB phenotype from
two consanguineous families. The clinical findings of EDS kyphoscoliotic type (EDS type VIA …