With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The key role of the bacterial ribosome makes it an important target for antibacterial agents.
Indeed, a large number of clinically useful antibiotics target this complex translational …

In this paper, we review recent DNA-binding agents that are expected to influence the field
of DNA-targeting. We restrict ourselves to binders for which the three-dimensional structure …

Nucleic acids are the molecular targets of many clinical anticancer drugs. However,
compared with proteins, nucleic acids have traditionally attracted much less attention as …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Aminoglycosides are highly potent, broad-spectrum antibiotics that exert their bactericidal
therapeutic effect by selectively binding to the decoding aminoacyl site (A-site) of the …

Apramycin is a structurally unique member of the 2-deoxystreptamine class of
aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that …

Aminoglycoside antibiotics interfere with the translation mechanism by binding to the tRNA
decoding site of the 16S ribosomal RNA. Crystallographic structures of aminoglycosides …

Aminoglycosides (AGs) are highly potent antibacterial agents, which are known to exert their
deleterious effects on bacterial cells by interfering with the translation process, leading to …

Premature termination codons (PTCs) are a cause of numerous genetic disorders spanning
diseases that affect children and adults, and are produced by base pair substitutions that …