Strain-based imaging techniques (and specifically speckle-tracking echocardiography) have
been shown to have clinical utility in a variety of settings. This technique is being embraced …

Hypertrophic cardiomyopathy (HCM) is an important genetic heart muscle disease for which
prevalence in the general population has not been completely resolved. For the past 20 …

Hypertrophic cardiomyopathy (HCM) is often caused by pathogenic variants in sarcomeric
genes and characterized by left ventricular (LV) hypertrophy, myocardial fibrosis and …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted through January 2011. Searches were limited to …

Background—Published nomograms of pediatric echocardiographic measurements are
limited by insufficient sample size to assess the effects of age, sex, race, and ethnicity …

The mechanisms by which truncating mutations in MYBPC3 (encoding cardiac myosin-
binding protein C; cMyBPC) or myosin missense mutations cause hypercontractility and …

Background Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a
proposed substrate for arrhythmias and heart failure. In animal models, profibrotic genetic …

Several lines of evidence suggest that the primary effect of hypertrophic cardiomyopathy
mutations in human β-cardiac myosin is hypercontractility of the heart, which leads to …

More than 350 individual MYPBC3 mutations have been identified in patients with inherited
hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations …

Human β-cardiac myosin exists in an ON-state where both myosin heads are accessible for
interaction with actin, and an OFF-state where the heads are folded back onto their own …