Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

The chemokine system, comprising 48 chemokines and 23 receptors, is critically involved in
several hallmarks of cancer. Yet, despite extensive efforts from the pharmaceutical sector …

Cytokine signaling is critical to a range of biological processes including cell development,
tissue repair, aging, and immunity. In addition to acting as key signal mediators of the …

The bone microenvironment is a complex tissue in which heterogeneous cell populations of
hematopoietic and mesenchymal origin interact with environmental cues to maintain tissue …

Several acute and chronic inflammatory diseases are driven by accumulation of activated
leukocytes due to enhanced chemokine expression. In addition to specific G protein-coupled …

The primary function of chemokines is to direct the migration of leukocytes to the site of injury
during inflammation. The effects of chemokines are modulated by several means, including …

The polyanionic nature and the ability to interact with proteins with different affinities are
properties of sulfated glycosaminoglycans (GAGs) that determine their biological function. In …

Controlled release of active biomolecules is an attractive approach to modulate chemotactic
gradients and accordingly the recruitment of cells, eg endothelial progenitor cells to improve …

In the first of two linked articles, we describe the development in the mechanisms underlying
allergy as described by Clinical & Experimental Allergy and other journals in 2018 …

Ischaemia-Reperfusion Injury (IRI) is a major contributor to acute organ dysfunction.
Chemokines play a key role in leukocyte recruitment to the injured tissue. CXCL8 is a critical …