Genomic medicine aims to improve health using the individual genomic data of people to
inform care. While clinical utility of genomic medicine in many monogenic, Mendelian …

PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …

After a diagnosis of unilateral breast cancer, increasing numbers of patients are requesting
contralateral prophylactic mastectomy (CPM), the surgical removal of the healthy breast after …

Background We sought to estimate the annual risk and 25-year cumulative risk of
contralateral breast cancer among women with stage 0–III unilateral breast cancer. Methods …

Background Prediction of contralateral breast cancer (CBC) risk is challenging due to
moderate performances of the known risk factors. We aimed to improve our previous risk …

Background Low-frequency variants play an important role in breast cancer (BC)
susceptibility. Gene-based methods can increase power by combining multiple variants in …

Purpose To evaluate the association between a previously published 313 variant–based
breast cancer (BC) polygenic risk score (PRS313) and contralateral breast cancer (CBC) …

PURPOSE A polygenic risk score (PRS) consisting of 313 common genetic variants
(PRS313) is associated with risk of breast cancer and contralateral breast cancer. This study …

Simple Summary Several risk prediction tools have been developed to better stratify women
according to their risk of developing breast cancer (BC) and inform prevention and early …

Breast cancer (BC) is the most common malignancy in American women.*, 1 Mortality has
declined, in part because screening detects cancers at an early stage. 2 For most women …