Myc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought
after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth …

This paper is in recognition of the 100th birthday of Dr. Herbert Tabor, a true pioneer in the
polyamine field for over 70 years, who served as the editor-in-chief of the Journal of …

G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …

Bromodomain and extra-terminal (BET) family proteins are key regulators of gene
expression in cancer. Herein, we utilize BRD4 profiling to identify critical pathways involved …

Cancer is a societal burden demanding innovative approaches. A major problem with the
conventional chemotherapeutic agents is their strong toxicity and other side effects due to …

The NME family of proteins is composed of 10 isoforms, designated NME1-10, which are
diverse in their enzymatic activities and patterns of subcellular localization. Each contains a …

DNA has the ability to form polymorphic structures like canonical duplex DNA and non-
canonical triplex DNA, Cruciform, Z-DNA, G-quadruplex (G4), i-motifs, and hairpin structures …

Over the past two decades biologists and bioinformaticians have unearthed substantial
evidence supporting a role for G-quadruplexes as important mediators of biological …

Developing c-MYC transcription inhibitors that target the G-quadruplex has generated
significant interest; however, few compounds have demonstrated specificity for c-MYC G …

G-quadruplexes are four-stranded nucleic acid secondary structures that are formed in
guanine-rich sequences. G-quadruplexes are widely distributed in functional regions of the …