Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting
infections and providing patients with optimal drug regimens require timely strain …

Highlights•Rapid diagnostics are essential in the fight against antimicrobial
resistance.•BioFire® FilmArray® panels can identify pathogen resistance genes in 1 …

The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …

Abstract Characterization of microbiomes has been enabled by high-throughput
metagenomic sequencing. However, existing methods are not designed to combine reads …

Rapid identification of bacterial pathogens is crucial for appropriate and adequate antibiotic
treatment, which significantly improves patient outcomes. 16S ribosomal RNA (rRNA) gene …

The increasing incidence of bloodstream infections including sepsis is a major challenge in
intensive care units worldwide. However, current diagnostics for pathogen identification …

Massive DNA sequencing studies have expanded our insights and understanding of the
ecological and functional characteristics of the gut microbiome. Advanced sequencing …

Clinical metagenomics (CMg) is the discipline that refers to the sequencing of all nucleic
acid material present within a clinical specimen with the intent to recover clinically relevant …

Bloodstream infection is a major cause of morbidity and mortality worldwide. We explored
whether MinION nanopore sequencing could accelerate diagnosis, resistance, and …

Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the
leading infectious cause of mortality. The “gold standard” for investigation of bacterial LRIs is …