Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Gadolinium retention: a research roadmap from the 2018 NIH/ACR/RSNA workshop on gadolinium chelates

RJ McDonald, D Levine, J Weinreb, E Kanal… - Radiology, 2018 - pubs.rsna.org
Gadolinium-based contrast agents (GBCAs) have revolutionized MRI, enabling physicians
to obtain crucial life-saving medical information that often cannot be obtained with other …

Gadolinium: pharmacokinetics and toxicity in humans and laboratory animals following contrast agent administration

J Davies, P Siebenhandl-Wolff, F Tranquart… - Archives of …, 2022 - Springer
Gadolinium-based contrast agents (GBCAs) have transformed magnetic resonance imaging
(MRI) by facilitating the use of contrast-enhanced MRI to allow vital clinical diagnosis in a …

The biological fate of gadolinium-based MRI contrast agents: a call to action for bioinorganic chemists

M Le Fur, P Caravan - Metallomics, 2019 - academic.oup.com
Gadolinium-based contrast agents (GBCAs) are widely used with clinical magnetic
resonance imaging (MRI), and 10 s of millions of doses of GBCAs are administered annually …

Update on Gadolinium-Based Contrast Agent Safety, From the AJR Special Series on Contrast Media

J Starekova, A Pirasteh, SB Reeder - American Journal of …, 2024 - ajronline.org
Since its introduction more than 35 years ago, gadolinium-enhanced MRI has fundamentally
changed medical practice. Although extraordinarily safe, gadolinium-based contrast agents …

Manganese-based contrast agents for magnetic resonance imaging of liver tumors: Structure–activity relationships and lead candidate evaluation

J Wang, H Wang, IA Ramsay, DJ Erstad… - Journal of medicinal …, 2018 - ACS Publications
Gd-based MRI contrast agents (GBCAs) have come under intense regulatory scrutiny due to
concerns of Gd retention and delayed toxicity. Three GBCAs comprising acyclic Gd chelates …

Gadolinium-based contrast agents—review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on …

E Blumfield, DW Swenson, RS Iyer, AL Stanescu - Pediatric radiology, 2019 - Springer
Gadolinium has been used as a base for contrast agents in MRI for the last three decades.
Numerous studies over the last 4 years have reported increased signal intensity in deep …

[HTML][HTML] Dynamic MRI in the evaluation of the spine: state of the art

G Michelini, A Corridore, S Torlone… - Acta Bio Medica …, 2018 - ncbi.nlm.nih.gov
Introduction: Degenerative disease of the spine is a generic term encompassing a wide
range of different disease processes, which leads to spinal instability; traumatic/neoplastic …

Cumulative administrations of gadolinium-based contrast agents: risks of accumulation and toxicity of linear vs macrocyclic agents

L Chehabeddine, T Al Saleh, M Baalbaki… - Critical Reviews in …, 2019 - Taylor & Francis
Ever since gadolinium was found to deposit in the brain of patients with normal kidney
function by Kanda et al. in 2014, several studies have been conducted to evaluate its effect …

[HTML][HTML] High-resolution magnetic resonance imaging at 3T of pituitary gland: advantages and pitfalls

M Varrassi, FC Bellisari, F Bruno, P Palumbo… - Gland …, 2019 - ncbi.nlm.nih.gov
Magnetic resonance imaging (MRI) is the primary imaging tool for the evaluation of pituitary
gland pathology. In the last decades, MRI with high-field scanners has become widely used …