In September 2006, members of the Sex, Gender and Pain Special Interest Group of the
International Association for the Study of Pain met to discuss the following:(1) what is known …

The gut is the only organ that can display reflexes and integrative neuronal activity even
when isolated from the central nervous system. This activity can be triggered by luminal …

Background & Aims Irritable bowel syndrome (IBS) is a common disorder of gut–brain
interaction associated with significant disease burden. This American Gastroenterological …

Patients with functional gastrointestinal disorders (FGID) often experience emotional
distress, a perceived lack of validation, and an unsatisfactory experience with health care …

The bowel exhibits reflexes in the absence of CNS input. To do so, epithelial sensory
transducers, such as enterochromaffin (EC) cells, activate the mucosal processes of intrinsic …

OBJECTIVES: Irritable bowel syndrome (IBS) is a chronic functional disorder. 5-
Hydroxytryptamine (5-HT) is a key modulator of gastrointestinal sensorimotor function. Many …

This document addresses the design of trials to assess the efficacy of new treatments for
functional gastrointestinal disorders (FGID), emphasizing trials in irritable bowel syndrome …

Aliment Pharmacol Ther 2010; 32: 144–158 Summary Background Irritable bowel syndrome
(IBS) is a functional disorder of the gastrointestinal tract with a significant placebo response …

Post-infectious irritable bowel syndrome (PI-IBS) is a common disorder wherein symptoms of
IBS begin after an episode of acute gastroenteritis. Published studies have reported …

To evaluate therapies available for the treatment of irritable bowel syndrome, and provide
consensus recommendations for their use, a total of 51 double‐blind clinical trials using …