Since the discovery of muscle in the 19th century, myosins as molecular motors have been
extensively studied. However, in the last decade, a new functional super-relaxed (SRX) state …

Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

Rationale: Myofilament length-dependent activation (LDA) is the key underlying mechanism
of cardiac heterometric autoregulation, commonly referred as the Frank-Starling Law of the …

Classically, striated muscle contraction is initiated by calcium (Ca2+)-dependent structural
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …

Muscle contraction is produced via the interaction of myofilaments and is regulated so that
muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and …

Mavacamten is a FDA-approved small-molecule therapeutic designed to regulate cardiac
function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity …

Cardiac mechanics plays a crucial role in atrial and ventricular function, in the regulation of
growth and remodelling, in the progression of disease, and the response to treatment. The …

BACKGROUND: Modulating myosin function is a novel therapeutic approach in patients with
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …

Understanding the dynamics of a cardiac muscle twitch contraction is complex because it
requires a detailed understanding of the kinetic processes of the Ca 2+ transient, thin …

The myosin super-relaxed (SRX) state is central to striated muscle metabolic and functional
regulation. In skeletal muscle, SRX myosin are predominantly colocalized with myosin …