Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

Antibiotic resistance has increased significantly in the recent years, and has become a
global problem for human health and the environment. As a result, several technologies for …

Symptomatic treatment of neuropathic pain in small fibre neuropathy is often disappointing.
The finding of voltage-gated sodium channel mutations in small fibre neuropathy (with …

Background Small fiber neuropathy (SFN) is a severe and disabling chronic pain syndrome
with no causal and limited symptomatic treatment options. Mechanistically based individual …

The emergence of the CRISPR–Cas9 gene editing system has brought much hope and
excitement to the field of gene therapy and the larger scientific community. However, in order …

ABSTRACT Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominantly
inherited tumor predisposition syndrome with an incidence of one in 3000–4000 individuals …

Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and …

Exploiting bacterial DNA-acting enzymes and expanding their repertoire for genome
engineering have been major technological and conceptual advances in molecular biology …

Therapeutic gene editing is becoming more feasible with the emergence of the Clustered
Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein …

In recent studies, brain stimulation has shown promising potential to alleviate chronic pain.
Although studies have shown that stimulation of pain-related brain regions can induce pain …