Molecular imprinting is a powerful and yet simple method to create multifunctional binding
sites within a cross-linked polymer network. We report a new class of synthetic glucosidase …

Replication of the extraordinary catalysis of enzymes in synthetic systems is a long-standing
goal of scientists. Here we report a synthetic mimic of carbonic anhydrase capable of …

Distinction of chemical functionality by their local chemical environment is a skill mastered
by enzymes, evident from the selective synthesis, cleavage, and transformation of peptides …

Glycosidases are an important class of enzymes for performing the selective hydrolysis of
glycans. Although glycans can be hydrolyzed in principle by acidic water, hydrolysis with …

Although synthetic mimics of lectins can be extremely useful in biological and biomedical
research, molecular recognition of carbohydrates has been hampered by their strong …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used over-the-counter drugs and
their uncontrolled disposal is a significant environmental concern. Although their fluorescent …

Site isolation of catalysts can enable incompatible catalysts such as acid and base to be
used in one pot for enhanced efficiency and other benefits. Although many synthetic …

Enzymes frequently use unimpressive functional groups such as weak carboxylic acids for
efficient, highly selective catalysis including hydrolysis of acetals and even amides. Much …

N-acyl homoserine lactones (AHLs) are signal molecules used by a large number of gram-
negative bacteria in quorum sensing and their hydrolysis is known to inhibit biofilm …

Regulation of enzyme activity is key to dynamic processes in biology but is difficult to
achieve with synthetic systems. We here report molecularly imprinted nanoparticles with …