The inflammatory bowel diseases (Crohn's disease; ulcerative colitis) are idiopathic chronic
inflammatory disorders of the intestine and/or colon. A major advancement in our …

Inflammatory bowel diseases (IBD) are a complex group of diseases involving alterations in
mucosal immunity and gastrointestinal physiology during both initiation and progressive …

The T cell as a bridge between innate and adaptive immune systems: Implications for the
kidney. The immune system is classically divided into innate and adaptive components with …

Rather like a satellite navigation system directing a vehicle to a particular destination
defined by post-code, immune cells have homing molecules or “immune post-codes” …

Lymphocyte migration (homing) to specific tissues has an important role during protective
and pathological immune responses, including inflammatory bowel diseases. Lymphocytes …

Background: Overproduction of nitric oxide by the inducible form of nitric oxide synthase
(iNOS) has been implicated in colitis. Different authors have postulated both toxic and …

Background Cytokine mediated induction of the mucosal addressin cell adhesion molecule-
1 (MAdCAM-1) expression is associated with the onset and progression of inflammatory …

The dysregulated recruitment of leukocytes into the intestine is required for the initiation and
maintenance of inflammatory bowel disease (IBD). Several families of molecules regulate …

The accumulation of leukocytes in various tissues contributes to the pathogenesis of
numerous human autoimmune diseases. The integrin α4β7, expressed on the surface of B …

Oral dextran sodium sulfate (DSS, 3%) produces experimental colitis with many features of
human inflammatory bowel disease (IBD),(leukocyte extravasation, cachexia, and …