Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

In this review, we explain why and how rabbit monoclonal antibodies have become
outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic …

Alzheimer's disease (AD) is characterized by progressive accumulation of misfolded
proteins, which form senile plaques and neurofibrillary tangles, and the release of …

Regulation of amyloid-β (Aβ) precursor protein (APP) expression is complex. MicroRNAs
(miRNAs) are expected to participate in the molecular network that controls this process. The …

Copper is an essential metal present at high levels in the CNS. Its role as a cofactor in
mitochondrial ATP production and in essential cuproenzymes is well defined. Menkes and …

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a
polyglutamine-encoding CAG expansion in the huntingtin gene. Iron accumulates in the …

Alzheimer's disease (AD) increases the risk for late-onset seizures and neuronal network
abnormalities. An elevated co-occurrence of AD and seizures has been established in the …

Protein misfolding and conformational changes are a cornerstone of neurodegenerative
diseases involving formation and deposition of toxic protein oligomers. Although mutations …