Neurodegenerative disorders are primarily characterized by neuron loss. The most common
neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Adolescence is a particularly vulnerable neurodevelopmental period marked by high rates
of engagement with risky alcohol use. This review summarizes the cognitive and neural …

Per occasion, alcohol consumption is higher in adolescents than in adults in both humans
and laboratory animals, with changes in the adolescent brain probably contributing to this …

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

The formation of new neurons in the adult central nervous system (CNS) has been
recognized as one of the major findings in neuroanatomical research. The hippocampal …

Stroke is the second cause of death and more importantly first cause of disability in people
over 40 years of age. Current therapeutic management of ischemic stroke does not provide …

In recent years, a substantial body of evidence has emerged demonstrating that purine and
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …

Gamma‐aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central
nervous system. GABA type A receptors (GABAAR s) are severely affected in Alzheimer's …

Alzheimer's disease (AD) is a major form of dementia. Abnormal amyloidogenic event-
mediated degeneration of cholinergic neurons in the cognitive centers of the brain has been …