Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Ionotropic glutamate receptors (iGluRs) are a major class of ligand‐gated ion channels that
are widespread in the living kingdom. Their critical role in excitatory neurotransmission and …

Kainate receptors (KARs) are a subtype of ionotropic glutamate receptors that control
synaptic transmission in the central nervous system and are implicated in neurological …

Since the 1990s, ionotropic glutamate receptors have served as an outstanding target for
drug discovery research aimed at the discovery of new neurotherapeutic agents. With the …

Glutamate-gated kainate receptors are ubiquitous in the central nervous system of
vertebrates, mediate synaptic transmission at the postsynapse and modulate transmitter …

Kainate receptors (KARs) are L-glutamate-gated ion channels that regulate synaptic
transmission and modulate neuronal circuits. KARs have strict assembly rules and primarily …

Ionotropic glutamate receptors (iGluRs) are tetrameric ion channels that mediate signal
transmission at neuronal synapses, where they contribute centrally to the postsynaptic …

The kainate receptors (KARs) are members of the ionotropic glutamate receptor family and
assemble into tetramers from a pool of five subunit types (GluK1–5). Each subunit confers …

Kainate receptors (KARs) are a subtype of ionotropic glutamate receptor (iGluR) channels, a
superfamily of ligand-gated ion channels which mediate the majority of excitatory …

Neural communication and modulation are complex processes. Ionotropic glutamate
receptors (iGluRs) significantly contribute to mediating the fast-excitatory branch of …