Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain

MW Ferenczy, LJ Marshall, CDS Nelson… - Clinical microbiology …, 2012 - Am Soc Microbiol
Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain

EO Major, K Amemiya, CS Tornatore… - Clinical microbiology …, 1992 - Am Soc Microbiol
Studies of the pathogenesis and molecular biology of JC virus infection over the last two
decades have significantly changed our understanding of progressive multifocal …

[HTML][HTML] Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia

DL Bohl, GA Storch, C Ryschkewitsch… - American Journal of …, 2005 - Elsevier
In a previous study, we performed serial BK virus (BKV), polymerase chain reaction (PCR)
and detected active BKV infection in 70 (35.4%) of 198 renal transplant recipients. In the …

Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection

MCG Monaco, PN Jensen, J Hou, LC Durham… - Journal of …, 1998 - Am Soc Microbiol
Progressive multifocal leukoencephalopathy is a demyelinating disease of the human
central nervous system that results from lytic infection of oligodendrocytes by the …

The human JC polyomavirus (JCPyV): virological background and clinical implications

HH Hirsch, P Kardas, D Kranz, C Leboeuf - Apmis, 2013 - Wiley Online Library
JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964,
PyV particles were revealed by electron microscopy in progressive multifocal …

JC virus DNA is present in many human brain samples from patients without progressive multifocal leukoencephalopathy

FA White 3rd, M Ishaq, GL Stoner, RJ Frisque - Journal of virology, 1992 - Am Soc Microbiol
Sections of normal and diseased brain and kidney tissues were screened for the presence
of JC virus (JCV) DNA by using the polymerase chain reaction. As expected, all samples …

Infection of human polyomaviruses JC and BK in peripheral blood leukocytes from immunocompetent individuals

K Dörries, E Vogel, S Günther, S Czub - Virology, 1994 - Elsevier
Widely disseminated infection with the human polyomaviruses JC and BK is followed by
lifelong asymptomatic viral persistence that can be reactivated under prolonged …

Evidence of human polyomavirus BK and JC infection in normal brain tissue

C Elsner, K Dörries - Virology, 1992 - Elsevier
Infection with the polyomaviruses JC and BK is ubiquitous in the human population and JCV
is the only virus associated with the central nervous system disease progressive multifocal …

Incidence of BK virus and JC virus viruria in human immunodeficiency virus-infected and-uninfected subjects

RB Markowitz, HC Thompson, JF Mueller… - Journal of Infectious …, 1993 - academic.oup.com
Abstract BK virus (BKV) and JC virus (JCV) are present within the renal system of most
adults. Reactivation may be linked to immunodeficiency, since many of the extant virus …

Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy

C Tornatore, JR Berger, SA Houff… - Annals of Neurology …, 1992 - Wiley Online Library
Progressive multifocal leukoencephalopathy (PML) results from lytic infection of
oligodendrocytes by JC virus (JCV). Although JCV has been identified in mononuclear cells …