Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Hepatitis C virus (HCV) infection and its complications have been the major cause of
cirrhosis and its complications for several decades in the Western world. Until recently …

Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member
galectin family that are evolutionarily highly conserved. It is the only chimeric protein with a …

Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of
extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to …

Galectin-3 protein is critical to the development of liver fibrosis because galectin-3 null mice
have attenuated fibrosis after liver injury. Therefore, we examined the ability of novel …

Galectin-3 (gal-3) is a β-galactoside-binding lectin, which regulates cell–cell and
extracellular interactions during self/non-self-antigen recognition and cellular activation …

Non-alcoholic steatohepatitis (NASH) and resultant liver fibrosis is a major health problem
without effective therapy. Some data suggest that galectin-3 null mice are resistant to the …

Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease
(NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH …

Galectin-3 (Gal3) is one of the most studied members of the galectin family that mediate
various biological processes such as growth regulation, immune function, cancer …

Fifteen galectins, β-galactose-binding animal lectins, are known to be distributed throughout
the body. We herein summarize current knowledge on the tissue-and cell-specific …