Nerve growth factor (NGF) was discovered in the early 1950s due to its trophic (survival-and
growth-promoting) effects on sensory and sympathetic neurons (Levi-Montalcini and …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

Pathophysiological activity and various kinds of traumatic insults are known to have
deleterious long-term effects on neuronal Cl− regulation, which can lead to a suppression of …

Various studies have shown that brain-derived neurotrophic factor (BDNF) increases
neuronal excitability and is localized and upregulated in areas implicated in …

A group of neurons with the characteristics of dentate gyrus granule cells was found at the
hilar/CA3 border several weeks after pilocarpine-or kainic acid-induced status epilepticus …

The rodent pilocarpine model of epilepsy exhibits hippocampal sclerosis and spontaneous
seizures and thus resembles human temporal lobe epilepsy. Use of the many available …

Temporal lobe epilepsy is a common form of drug-resistant epilepsy that sometimes
responds to dietary manipulation such as the'ketogenic diet'. Here we have investigated the …

Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

In the CNS, there are widespread and diverse interactions between growth factors and
estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic …

Epilepsy is one of the most common neurological disorders. Although epilepsy can be
idiopathic, it is estimated that up to 50% of all epilepsy cases are initiated by neurological …