Breast cancer is now the most frequently diagnosed cancer and leading cause of cancer
death in women worldwide. Strategies targeting the primary tumour have markedly …

Metastasis to bone frequently occurs in majority of patients with advanced breast cancer and
prostate cancer, leading to devastating skeletal-related events and substantially reducing …

Osteopontin (OPN) is a multifunctional cytokine that impacts cell proliferation, survival, drug
resistance, invasion, and stem like behavior. Due to its critical involvement in regulating …

Although chemotherapy is a conventional cancer treatment, it may induce a protumorigenic
microenvironment by triggering the release of proinflammatory mediators. In this study, we …

Introduction: Cancer is a complex pathological disorder, established as a result of
accumulation of genetic and epigenetic changes, which lead to adverse alterations in the …

Serum biomarkers are molecules produced by normal and abnormal cells. Prostate specific
antigen (PSA) is an example of a serum biomarker used widely in the diagnosis and …

Prostate cancer (PCa) causes deaths worldwide, ranking second after lung cancer. Bone
metastasis (BM) frequently results from advanced PCa, affecting approximately 90% of …

Prostate cancer stem-like cells (PCSLC) are believed to be responsible for prostate cancer
onset and metastasis. Autocrine and microenvironmental signals dictate PCSLC behavior …

Simple Summary Bone metastasis can develop from several tumor subtypes, and the
presence of bone metastasis confers a negative prognosis to patients. In dogs, a small …

Prostate cancer (CaP) is the most commonly diagnosed malignancy in males in the Western
world with one in six males diagnosed in their lifetime. Current clinical prognostication …