The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

Abstract Inositol 1, 4, 5‐trisphosphate (IP3) is a second messenger that induces the release
of Ca2+ from the endoplasmic reticulum (ER). The IP3 receptor (IP3R) was discovered as a …

Proteins of the 4.1 family are characteristic of eumetazoan organisms. Invertebrates contain
single 4.1 genes and the Drosophila model suggests that 4.1 is essential for animal life …

Proto-oncogenes and tumor suppressors critically control cell-fate decisions like cell
survival, adaptation and death. These processes are regulated by Ca2+ signals arising from …

Great insight has been gained into the structure and function of the inositol 1, 4, 5
trisphosphate receptor (InsP3R) by studies employing mutagenesis of the cDNA encoding …

Synaptic plasticity enhances or reduces connections between neurons, affecting learning
and memory. Postsynaptic AMPARs mediate greater than 90% of the rapid excitatory …

Regulation of inositol 1, 4, 5-trisphosphate (IP 3) receptors (IP 3 R) by IP 3 and Ca 2+ allows
them to initiate and regeneratively propagate intracellular Ca 2+ signals. The distribution …

Ca2+ activation of Cl and K channels is a key event underlying stimulated fluid secretion
from parotid salivary glands. Cl channels are exclusively present on the apical plasma …

Scaffolding protein 4.1 N is a neuron-enriched 4.1 homologue. 4.1 N contains three
conserved domains, including the N-terminal 4.1-ezrin-radixin-moesin (FERM) domain …

IRBIT (IP 3 Rs binding protein released with IP 3) is a protein originally identified by the
Mikoshiba group as an inhibitor of IP 3 receptors function. Subsequently it was found to have …