Top-down mass spectrometry (MS)-based proteomics is a powerful technology for
comprehensively characterizing proteoforms to decipher post-translational modifications …

Untitled Page 1 Page 2 JUNE 1, 2004 / ANALYTICAL CHEMISTRY 197 A he timeline for
maturation of a new measurement approach is difficult to predict but often accelerates as more …

Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem
mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an …

This review provides a broad overview of recent Fourier transform ion cyclotron resonance
(FTICR) applications and technological developments relevant to the field of proteomics …

A method for rapid sequencing of intact proteins simultaneously from the N and C termini (1–
2 s) with online chromatography is described and applied to the characterization of histone …

The introduction of electron capture dissociation (ECD) to electrospray (ESI) Fourier
transform ion cyclotron resonance mass spectrometry (FT‐ICR MS) constitutes a significant …

Proteomics includes identification and quantification of proteins and the characterization of
protein modifications, such as posttranslational modifications and sequence variants. The …

Top-down mass spectrometry is an emerging approach for the analysis of intact proteins.
The term was coined as a contrast with the better-established, bottom-up strategy for …

In eukaryotes, the combinatorial potential of carbohydrates is used for the modulation of
protein function. However, despite the wealth of cell wall and surface-associated …

Although the advent of large-scale genomic sequencing has greatly simplified the task of
determining the primary structures of peptides and proteins, the genomic sequences of …