One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

We grafted human spinal cord–derived neural progenitor cells (NPCs) into sites of cervical
spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug …

Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

The corticospinal tract (CST) is the most important motor system in humans, yet robust
regeneration of this projection after spinal cord injury (SCI) has not been accomplished. In …

Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing
growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells …

Background. Spinal cord injury (SCI) is one of the serious neurological diseases that occur
in young people with high morbidity and disability. However, there is still a lack of effective …

Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were
differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal …

After years of incremental progress, several recent studies have succeeded in deriving
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …