The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

G Morris, CC Bortolasci, BK Puri, L Olive, W Marx… - Life sciences, 2020 - Elsevier
In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

L Zeng, K Yang, G Yu, W Hao, X Zhu, A Ge… - Cell Death & …, 2024 - nature.com
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis
remain unclear. Currently, increasing research has highlighted the role of ferroptosis in …

Pathogenic role of fibrinogen in the neuropathology of multiple sclerosis: a tale of sorrows and fears

M Alruwaili, HM Al-Kuraishy, A Alexiou… - Neurochemical …, 2023 - Springer
Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the
central nervous system (CNS) due to injury of the myelin sheath by immune cells. The …

Oxidative/nitroxidative stress and multiple sclerosis

TO Tobore - Journal of Molecular Neuroscience, 2021 - Springer
Multiple sclerosis (MS) is a multifactorial, central nervous system, immune-mediated disease
characterized by inflammation, demyelination, and neurodegeneration. Evidence suggests a …

Neuroendocrine, neuroinflammatory and pathological outcomes of chronic stress: A story of microglial remodeling

K Picard, MK St-Pierre, HA Vecchiarelli… - Neurochemistry …, 2021 - Elsevier
Microglia, the resident macrophage cells of the central nervous system (CNS), are involved
in a myriad of processes required to maintain CNS homeostasis. These cells are dynamic …

An integrative approach to neuroinflammation in psychiatric disorders and neuropathic pain

DI Lurie - Journal of experimental neuroscience, 2018 - journals.sagepub.com
Neuroinflammation is a complex process involving both the peripheral circulation and the
Central Nervous System (CNS) and is considered to underlie many CNS disorders including …

Oxidative stress and antioxidant defenses in mild cognitive impairment: A systematic review and meta-analysis

G Nantachai, A Vasupanrajit, C Tunvirachaisakul… - Ageing Research …, 2022 - Elsevier
This study aims to systematically review and meta-analyze the nitro-oxidative stress
(O&NS)/antioxidant (ANTIOX) ratio in the peripheral blood of people with mild cognitive …

Neuroimmune mechanisms as novel treatment targets for substance use disorders and associated comorbidities

MD Namba, JM Leyrer-Jackson, EK Nagy… - Frontiers in …, 2021 - frontiersin.org
Recent studies examining the neurobiology of substance abuse have revealed a significant
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …

The effects of Ellagic acid supplementation on neurotrophic, inflammation, and oxidative stress factors, and indoleamine 2, 3-dioxygenase gene expression in multiple …

G Hajiluian, SJ Karegar, F Shidfar, N Aryaeian… - Phytomedicine, 2023 - Elsevier
Background Depression is one of the most common psychological disorders among multiple
sclerosis (MS) patients that characterized as the first symptoms. Ellagic acid is a natural …

Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: Insights into underlying molecular mechanisms

S Sadraie, Z Kiasalari, M Razavian, S Azimi… - Metabolic Brain …, 2019 - Springer
Systemic lipopolysaccharide (LPS) triggers neuroinflammation with consequent
development of behavioral and cognitive deficits. Neuroinflammation plays a crucial role in …