Smart wound dressings for diabetic chronic wounds

E Gianino, C Miller, J Gilmore - Bioengineering, 2018 - mdpi.com
Given their severity and non-healing nature, diabetic chronic wounds are a significant
concern to the 30.3 million Americans diagnosed with diabetes mellitus (2015). Peripheral …

Zinc Oxide Nanoparticles as Potential Delivery Carrier: Green Synthesis by Aspergillus niger Endophytic Fungus, Characterization, and In Vitro/In Vivo Antibacterial …

DH Abdelkader, WA Negm, E Elekhnawy, D Eliwa… - Pharmaceuticals, 2022 - mdpi.com
We aimed to synthesize zinc oxide nanoparticles (ZnO NPs) using the endophytic fungal
extract of Aspergillus niger. The prepared ZnO NPs were characterized, and their in vitro and …

Co-delivery of gentiopicroside and thymoquinone using electrospun m-PEG/PVP nanofibers: In-vitro and In vivo studies for antibacterial wound dressing in diabetic …

M Almukainzi, TA El-Masry, WA Negm… - International journal of …, 2022 - Elsevier
Nanofibers (NFs) provide several delivery advantages like their great flexibility and similarity
with extracellular matrix (ECM) which qualify them to be the unique model of a wound …

Cytotoxicity profiling of deep eutectic solvents to human skin cells

IPE Macário, H Oliveira, AC Menezes, SPM Ventura… - Scientific reports, 2019 - nature.com
The tailor-made character of deep eutectic solvents (DES) turns them very attractive to be
used in several applications, including in health-related areas such as pharmaceutical …

Nanocarrier-mediated topical insulin delivery for wound healing

AS Macedo, F Mendes, P Filipe, S Reis, P Fonte - Materials, 2021 - mdpi.com
Wound care has been clinically demanding due to inefficacious treatment that represents an
economic burden for healthcare systems. In Europe, approximately 7 million people are …

A novel sustained anti-inflammatory effect of atorvastatin—calcium PLGA nanoparticles: in vitro optimization and in vivo evaluation

DH Abdelkader, AK Abosalha, MA Khattab… - Pharmaceutics, 2021 - mdpi.com
Atorvastatin Calcium (At-Ca) has pleiotropic effect as anti-inflammatory drug beside its main
antihyperlipidemic action. Our study was conducted to modulate the anti-inflammatory effect …

Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly (vinyl alcohol)-borate hydrogels

DH Abdelkader, MM Tambuwala, CA Mitchell… - Drug delivery and …, 2018 - Springer
Insulin plays an important role in the wound healing process, but its method of delivery to the
wound bed and subsequent effect on rate of healing is less well investigated. In this study …

Novel drug delivery systems

AM Faheem, DH Abdelkader - Engineering drug delivery systems, 2020 - Elsevier
The field of nanomedicine employs novel drug delivery systems (NDDSs) to overcome the
limitations of traditional dosage forms. Conventional formulations are associated with poor …

Gentiopicroside PLGA nanospheres: fabrication, in vitro characterization, antimicrobial action, and in vivo effect for enhancing wound healing in diabetic rats

M Almukainzi, TA El-Masry, WA Negm… - International Journal …, 2022 - Taylor & Francis
Purpose Gentiopicroside (GPS), an adequate bioactive candidate, has a promising
approach for enhancing wound healing due to its antioxidant and antimicrobial properties …

Chitosan-insulin nano-formulations as critical modulators of inflammatory cytokines and Nrf-2 pathway to accelerate burn wound healing

D Sharda, S Ghosh, P Kaur, B Basu, D Choudhury - Discover Nano, 2023 - Springer
Burn injuries are characterized by prolonged inflammatory phases, neurovascular damage,
and hypermetabolism, eventually causing improper tissue regeneration. Insulin has gained …