MicroRNAs in epilepsy: pathophysiology and clinical utility

DC Henshall, HM Hamer, RJ Pasterkamp… - The Lancet …, 2016 - thelancet.com
Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …

The epigenetics of epilepsy and its progression

RM Hauser, DC Henshall, FD Lubin - The Neuroscientist, 2018 - journals.sagepub.com
Epilepsy is a common and devastating neurological disorder characterized by recurrent and
unprovoked spontaneous seizures. One leading hypothesis for the development and …

Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy

R Raoof, S Bauer, H El Naggar, NMC Connolly… - …, 2018 - thelancet.com
Background There are no blood-based molecular biomarkers of temporal lobe epilepsy
(TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong …

Functionalized platinum nanoparticles with biomedical applications

SY Gutiérrez de la Rosa, R Muñiz Diaz… - International Journal of …, 2022 - mdpi.com
Functionalized platinum nanoparticles have been of considerable interest in recent research
due to their properties and applications, among which they stand out as therapeutic agents …

Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus

R Raoof, EM Jimenez-Mateos, S Bauer… - Scientific reports, 2017 - nature.com
There is a need for diagnostic biomarkers of epilepsy and status epilepticus to support
clinical examination, electroencephalography and neuroimaging. Extracellular microRNAs …

The challenge of microRNA as a biomarker of epilepsy

Y Ma - Current Neuropharmacology, 2018 - ingentaconnect.com
Background: Epilepsy is one of chronic severe neurological disorders possess to recurring
seizures. And now anti-epileptic drugs are only effective in less than one third of epilepsy …

“TORNADO”–Theranostic One-Step RNA Detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid

H McArdle, EM Jimenez-Mateos, R Raoof, E Carthy… - Scientific reports, 2017 - nature.com
Diagnosis of seizure disorders such as epilepsy currently relies on clinical examination and
electroencephalogram recordings and is associated with substantial mis-diagnosis. The …

Recent developments in diagnosis of epilepsy: scope of MicroRNA and technological advancements

R Bandopadhyay, T Singh, MM Ghoneim, S Alshehri… - Biology, 2021 - mdpi.com
Simple Summary Through epilepsy is one of the leading causes of poor mental health,
increased school dropout, and socioeconomic burden, yet the diagnosis remains a …

Discovery and validation of blood micro RNA s as molecular biomarkers of epilepsy: Ways to close current knowledge gaps

N Enright, M Simonato, DC Henshall - Epilepsia Open, 2018 - Wiley Online Library
There is a major unmet need for biomarkers of epilepsy. Biofluids such as blood offer a
potential source of molecular biomarkers. Micro RNA s (miRNAs) fulfill several key …

Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity

U Bekenstein, N Mishra… - Proceedings of the …, 2017 - National Acad Sciences
Epilepsy is a common neurological disease, manifested in unprovoked recurrent seizures.
Epileptogenesis may develop due to genetic or pharmacological origins or following injury …