Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Ferroptosis is an iron-and lipid peroxidation (LPO)-mediated programmed cell death type.
Recently, mounting evidence has indicated the involvement of ferroptosis in …

Genetics, age, environmental factors, and oxidative stress have all been implicated in the
development of Parkinson's disease (PD); however, a complete understanding of its …

Vitamin D deficiency is believed to affect between 35 and 55% of the world's population,
making it a hidden pandemic. In addition to its role in bone and calcium homeostasis …

Iron is essential for all organisms and cells. Diseases of iron imbalance affect billions of
patients, including those with iron overload and other forms of iron toxicity. Excess iron load …

There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

Renal I/R injury is a severe medical condition contributing to acute kidney injury (AKI),
leading to rapid kidney dysfunction and high mortality rates. It is generally observed during …

The design of clinical protocols and the selection of drugs with appropriate posology are
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …

γ-Glutamyl moiety that is attached to the cysteine (Cys) residue in glutathione (GSH) protects
it from peptidase-mediated degradation. The sulfhydryl group of the Cys residue represents …