The NMDA receptor is a Ca2+-permeant glutamate receptor which plays key roles in health
and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A and 2B are …

Schizophrenia is a heterogeneous psychiatric disorder with a strong genetic basis, whose
etiology and pathophysiology remain poorly understood. Exome sequencing studies have …

N-methyl-D-aspartate receptors (NMDAR) are ligand-gated ion channels mediating
excitatory neurotransmission and are important for normal brain development, cognitive …

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors
that mediate a calcium-permeable component to fast excitatory neurotransmission. NMDARs …

Background and Objectives Pathogenic variants in GRIN2A are associated with a spectrum
of epilepsy-aphasia syndromes (EASs). Seizures as well as speech and language disorders …

ANK3 encodes ankyrin‐G, a protein involved in neuronal development and signaling.
Alternative splicing gives rise to three ankyrin‐G isoforms comprising different domains with …

Objective N‐methyl‐D‐aspartate receptors are glutamate‐gated ion channels that play a
crucial role in brain function. Numerous inherited or de novo variants in the GRIN2A gene …

Epilepsy is a chronic neurological disorder characterized by repeated seizures, ie periods of
paroxysmal brain activity commonly attributed to an imbalance between excitatory and …

N-methyl-D-aspartate receptors (NMDARs) are excitatory glutamate-gated ion channels that
are expressed throughout the central nervous system. NMDARs mediate calcium entry into …