Mammalian sex determination is triggered by activation of the mammalian sex-determining
gene, Sry, in a spatially and temporally controlled manner. Because reduced or delayed Sry …

The mammalian Y chromosome is considered a symbol of maleness, as it encodes a gene
driving male sex determination, Sry, as well as a battery of other genes important for male …

In mice, the entry of germ cells into meiosis crucially depends on the expression of
stimulated by retinoic acid gene 8 (Stra8). Stra8 is expressed specifically in pre-meiotic germ …

In eutherian mammals, gonadal sex is determined by the presence or absence of the sex-
determining region Y (SRY) gene, which locates in the male-specific region of the Y …

Methods and compositions are provided for generating targeted genetic modifications on the
Y chromosome or a challenging target locus. Compositions include an in vitro culture …

In most mammals, sex determination is initiated by transient expression of Sry, Sex-
determining region Y gene, encoding an HMG-box transcription factor in bipotential gonadal …

抄録 性的に未分化な生殖腺が将来精巣になるのか卵巣になるのか, その方向付けのことを性決定
と呼ぶ. ほ乳類の性決定には性染色体の組み合わせが重要である. Y 染色体を持つ個体では精巣 …

Germ cells have the unique ability to perform a specialised form of cell division called
meiosis that enables the generation of haploid gametes, sperm and oocyte. In mammals …