Roles of circadian clocks in cancer pathogenesis and treatment

Y Lee - Experimental & molecular medicine, 2021 - nature.com
Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h
rhythms in cellular and bodily functions across nearly all living species. These internal clock …

Circadian rhythms, disease and chronotherapy

Y Lee, JM Field, A Sehgal - Journal of biological rhythms, 2021 - journals.sagepub.com
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway

A Vallée, Y Lecarpentier, JN Vallée - Journal of Experimental & Clinical …, 2019 - Springer
Numerous studies have presented that curcumin could have a positive effect in the
prevention of cancer and then in tumor therapy. Several hypotheses have highlighted that …

Chronotherapy in Glioblastoma: state of the art and future perspectives

M Petković, M Henis, O Heese, A Relógio - EBioMedicine, 2023 - thelancet.com
Circadian rhythms regulate various processes in the human body, including drug
metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the …

Thermodynamics in gliomas: interactions between the canonical WNT/beta-catenin pathway and PPAR gamma

A Vallée, Y Lecarpentier, R Guillevin… - Frontiers in …, 2017 - frontiersin.org
Gliomas cells are the site of numerous metabolic and thermodynamics abnormalities with an
increasing entropy rate which is characteristic of irreversible processes driven by changes in …

Health benefits of dietary chronobiotics: beyond resynchronizing internal clocks

J Huang, M Lu, CT Ho - Food & function, 2021 - pubs.rsc.org
The internal circadian clock in mammals drives whole-body biological activity rhythms. The
clock reflects changes in external signals by controlling enzyme functions and the release of …

Cancer stem cell generation during epithelial-mesenchymal transition is temporally gated by intrinsic circadian clocks

A De, DH Beligala, VP Sharma, CA Burgos… - Clinical & Experimental …, 2020 - Springer
Epithelial-mesenchymal transition (EMT) is a key event preceding tumor cell metastasis that
increases cell invasiveness and cancer stem cell (CSC) populations. Studies suggest that …

Resveratrol induces the fasting state and alters circadian metabolism in hepatocytes

O Chatam, N Chapnik, O Froy - Plant Foods for Human Nutrition, 2022 - Springer
Resveratrol is a nutritional substance that has both metabolic and circadian effects. While
some studies indicate a correlation between resveratrol and reduced gluconeogenesis …

[HTML][HTML] The timing of caffeic acid treatment with cisplatin determines sensitization or resistance of ovarian carcinoma cell lines

R Sirota, D Gibson, R Kohen - Redox Biology, 2017 - Elsevier
Cisplatin is a widely used chemotherapeutic drug showing high efficiency in the treatment of
primary tumors such as ovarian, testicular and cervical cancers. The major drawback of …

pH-sensitive nanocarriers for curcumin delivery in cancer therapy

V Mohammadzadeh, MR Zirak, H Kamali… - Journal of Drug Delivery …, 2021 - Elsevier
Cancer is a group of diseases that cause high mortality worldwide. Current strategies for
cancer treatment include chemotherapy, immunotherapy, radiation therapy, hormone …