Chalcone derivatives: role in anticancer therapy

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Concept of hybrid drugs and recent advancements in anticancer hybrids

AK Singh, A Kumar, H Singh, P Sonawane, H Paliwal… - Pharmaceuticals, 2022 - mdpi.com
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Molecular targets and anticancer activity of quinoline–chalcone hybrids: Literature review

MFA Mohamed, GEDA Abuo-Rahma - RSC advances, 2020 - pubs.rsc.org
α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …

Roles of histone deacetylases and inhibitors in anticancer therapy

FA Verza, U Das, AL Fachin, JR Dimmock, M Marins - Cancers, 2020 - mdpi.com
Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …

Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors

AKA Bass, MS El-Zoghbi, ESM Nageeb… - European journal of …, 2021 - Elsevier
Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment,
innovation and development of new effective anticancer candidates still represents a …

Microwave-assisted synthesis of pyrano [2, 3-c]-pyrazole derivatives and their anti-microbial, anti-malarial, anti-tubercular, and anti-cancer activities

PH Parikh, JB Timaniya, MJ Patel, KP Patel - Journal of Molecular Structure, 2022 - Elsevier
We have described solvent-free preparation of new pyrano [2, 3-c]-pyrazole-5-carbonitriles
(1-10) from the reaction of 1, 3-diketo ester, aryl hydrazine, aromatic aldehyde, and …

Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential …

AHH Ahmed, MFA Mohamed, RM Allam, A Nafady… - Bioorganic …, 2022 - Elsevier
Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development
thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …

Chalcones and gastrointestinal cancers: experimental evidence

R Michalkova, M Kello, M Cizmarikova… - International Journal of …, 2023 - mdpi.com
Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers
with a high incidence rate worldwide. The current treatment including surgery …

Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors

AKA Bass, ESM Nageeb, MS El-Zoghbi… - Bioorganic …, 2022 - Elsevier
Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …

Novel 1, 2, 4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study

TS Ibrahim, AJ Almalki, AH Moustafa, RM Allam… - Bioorganic …, 2021 - Elsevier
New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant
bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …