Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in medicinal chemistry, especially in the identification and development of potential anticancer …
Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/ deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …
AKA Bass, MS El-Zoghbi, ESM Nageeb… - European journal of …, 2021 - Elsevier
Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment, innovation and development of new effective anticancer candidates still represents a …
We have described solvent-free preparation of new pyrano [2, 3-c]-pyrazole-5-carbonitriles (1-10) from the reaction of 1, 3-diketo ester, aryl hydrazine, aromatic aldehyde, and …
Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …
R Michalkova, M Kello, M Cizmarikova… - International Journal of …, 2023 - mdpi.com
Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers with a high incidence rate worldwide. The current treatment including surgery …
Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3- cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …
New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …