Engineering the interface between inorganic nanoparticles and biological systems through ligand design
Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological
applications. These applications are enabled through molecular design of surface …
applications. These applications are enabled through molecular design of surface …
Identifying hydrophobic protein patches to inform protein interaction interfaces
Interactions between proteins lie at the heart of numerous biological processes and are
essential for the proper functioning of the cell. Although the importance of hydrophobic …
essential for the proper functioning of the cell. Although the importance of hydrophobic …
Learning the relationship between nanoscale chemical patterning and hydrophobicity
NB Rego, AL Ferguson… - Proceedings of the …, 2022 - National Acad Sciences
The hydrophobicity of proteins and similar surfaces, which display chemical heterogeneity at
the nanoscale, drives countless aqueous interactions and assemblies. However, predicting …
the nanoscale, drives countless aqueous interactions and assemblies. However, predicting …
The interplay of ligand properties and core size dictates the hydrophobicity of monolayer-protected gold nanoparticles
The hydrophobicity of monolayer-protected gold nanoparticles is a crucial design parameter
that influences self-assembly, preferential binding to proteins and membranes, and other …
that influences self-assembly, preferential binding to proteins and membranes, and other …
Spotting Local Environments in Self-Assembled Monolayer-Protected Gold Nanoparticles
Organic–inorganic (O–I) nanomaterials are versatile platforms for an incredible high number
of applications, ranging from heterogeneous catalysis to molecular sensing, cell targeting …
of applications, ranging from heterogeneous catalysis to molecular sensing, cell targeting …
Interfacial water and ion distribution determine ζ potential and binding affinity of nanoparticles to biomolecules
The molecular features that dictate interactions between functionalized nanoparticles and
biomolecules are not well understood. This is in part because for highly charged …
biomolecules are not well understood. This is in part because for highly charged …
Small-angle neutron scattering differentiates molecular-level structural models of nanoparticle interfaces
Y Wu, X Liu, A Radulescu, L Porcar, A Krause-Heuer… - Nanoscale, 2025 - pubs.rsc.org
The highly anisotropic and nonadditive nature of nanoparticle surfaces restricts their
characterization by limited types of techniques that can reach atomic or molecular resolution …
characterization by limited types of techniques that can reach atomic or molecular resolution …
Ligand length and surface curvature modulate nanoparticle surface heterogeneity and electrostatics
Motivated by the recent nuclear magnetic resonance (NMR) analysis of functionalized gold
nanoparticles (J. Am. Chem. Soc., 141, 2019, 4316–4327), we conduct explicit solvent …
nanoparticles (J. Am. Chem. Soc., 141, 2019, 4316–4327), we conduct explicit solvent …
Identifying nonadditive contributions to the hydrophobicity of chemically heterogeneous surfaces via dual-loop active learning
AS Kelkar, BC Dallin, RC Van Lehn - The Journal of Chemical Physics, 2022 - pubs.aip.org
Hydrophobic interactions drive numerous biological and synthetic processes. The materials
used in these processes often possess chemically heterogeneous surfaces that are …
used in these processes often possess chemically heterogeneous surfaces that are …
Water interactions with complex surfaces
A Murello - 2020 - infoscience.epfl.ch
The solvent accessible surface area of proteins is very complex, mainly because it is
composed of domains with different degrees of affinity for water. The domains nature and …
composed of domains with different degrees of affinity for water. The domains nature and …