Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

High mortality and morbidity rates and variable clinical behavior are hallmarks of
glioblastoma (GBM), the most common and aggressive primary malignant brain tumor …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …

Multidrug resistance is a key determinant of cancer chemotherapy failure. One of the major
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …

Members of the miR-34 family are induced by the tumor suppressor p53 and are known to
inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the …

Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

The microRNA (miRNA)-34a is a key regulator of tumor suppression. It controls the
expression of a plethora of target proteins involved in cell cycle, differentiation and …

Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and
metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs,,,, and …