Protein modification of living cells using sortase

LK Swee, HL Ploegh - US Patent 11,492,590, 2022 - Google Patents
Non-genetically engineered mammalian cells modified by sortase-mediated conjugation of
an agent thereto are provided. Methods of conjugating agents to non-genetically engineered …

Labeling of antibodies

M Rashidian, HL Ploegh - US Patent 12,048,753, 2024 - Google Patents
2018-10-01 Assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
reassignment WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ASSIGNMENT OF …

Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application

Z Wu, Z Zha, LIU Futao, K Ploessl, SR Choi… - US Patent …, 2021 - Google Patents
The present invention relates to deuterated compounds according to Formula IA, Formula II-
A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents …

18F labeling of proteins using sortases

M Rashidian, HL Ploegh, R Weissleder… - US Patent …, 2023 - Google Patents
2020-03-02 Assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
reassignment WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ASSIGNMENT OF …

Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application

Z Wu, Z Zha, LIU Futao, K Ploessl, SR Choi… - US Patent …, 2021 - Google Patents
The present invention relates to deuterated compounds according to Formula IA, Formula II-
A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents …

In vitro production of red blood cells with proteins comprising sortase recognition motifs

H Lodish, HL Ploegh, HY Lee, J Shi, L Hoffman… - US Patent …, 2024 - Google Patents
2020-03-03 Assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
reassignment WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ASSIGNMENT OF …