The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
Genome-wide effects on Escherichia coli transcription from ppGpp binding to its two sites on RNA polymerase
P Sanchez-Vazquez, CN Dewey… - Proceedings of the …, 2019 - National Acad Sciences
The second messenger nucleotide ppGpp dramatically alters gene expression in bacteria to
adjust cellular metabolism to nutrient availability. ppGpp binds to two sites on RNA …
adjust cellular metabolism to nutrient availability. ppGpp binds to two sites on RNA …
Advances in applying computer-aided drug design for neurodegenerative diseases
Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …
Microbial adaptation to enhance stress tolerance
Microbial cell factories have been widely used in the production of various chemicals.
Although synthetic biology is useful in improving the cell factories, adaptation is still widely …
Although synthetic biology is useful in improving the cell factories, adaptation is still widely …
(p) ppGpp: magic modulators of bacterial physiology and metabolism
W Steinchen, V Zegarra, G Bange - Frontiers in Microbiology, 2020 - frontiersin.org
When bacteria experience growth-limiting environmental conditions, the synthesis of the
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
An interbacterial toxin inhibits target cell growth by synthesizing (p) ppApp
Bacteria have evolved sophisticated mechanisms to inhibit the growth of competitors. One
such mechanism involves type VI secretion systems, which bacteria can use to inject …
such mechanism involves type VI secretion systems, which bacteria can use to inject …
Regulatory themes and variations by the stress-signaling nucleotide alarmones (p) ppGpp in bacteria
Bacterial stress-signaling alarmones are important components of a protective network
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …
Characterization of Autoinducer-3 Structure and Biosynthesis in E. coli
Escherichia coli is a common inhabitant of the human microbiota and a beacon model
organism in biology. However, an understanding of its signaling systems that regulate …
organism in biology. However, an understanding of its signaling systems that regulate …
Coupled transcription-translation in prokaryotes: an old couple with new surprises
M Irastortza-Olaziregi, O Amster-Choder - Frontiers in Microbiology, 2021 - frontiersin.org
Coupled transcription-translation (CTT) is a hallmark of prokaryotic gene expression. CTT
occurs when ribosomes associate with and initiate translation of mRNAs whose transcription …
occurs when ribosomes associate with and initiate translation of mRNAs whose transcription …