Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the
globe and is one of the main complications in patients with type 1 and 2 diabetes. The …

Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …

The inflammatory component of diabetic kidney disease has become of great interest in
recent years, with genetic and epigenetic variants playing a fundamental role in the initiation …

Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …

The gene editing tool CRISPR-Cas has become the foundation for developing numerous
molecular systems used in research and, increasingly, in medical practice. In particular, Cas …

A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific
therapies. Here we show that glucose-mediated changes in gene expression largely persist …

Diabetic nephropathy (DN), which is a common microvascular complication with a high
incidence in diabetic patients, greatly increases the mortality of patients. With further study …

Diabetic kidney disease (DKD) is one of the most common microvascular complication of
both type 1 (T1DM) and type 2 diabetes mellitus (T2DM), and the leading cause of end …

Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …