Measuring anxiety-like behaviour in mice has been mostly undertaken using a few classical
animal models of anxiety such as the elevated plus-maze, the light/dark choice or the open …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

The concept of moderate consumption of ethanol (beverage alcohol) has evolved over time
from considering this level of intake to be nonintoxicating and noninjurious, to …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Human preterm neonates are subjected to repetitive pain during neonatal intensive care.
We hypothesized that exposure to repetitive neonatal pain may cause permanent or long …

This review discusses efforts to develop rodent models for the study of neurobiological
mechanisms underlying chronic alcohol drinking, alcoholism, and abnormal alcohol-seeking …

Alcoholism is a complex brain disease characterized by three distinct stages of the addiction
cycle that manifest as neuroadaptive changes in the brain. One such stage of the addiction …

Alcoholism is a chronic relapsing disorder with substantial heritability. Uncovering gene–
environment interactions underlying this disease process can aid identification of novel …

Individuals diagnosed with anxietyrelated illnesses are at increased risk of developing
alcoholism, exhibit a telescoped progression of this disease and fare worse in recovery …

A long-debatedtension reduction'hypothesis postulates anti-anxiety effects to be important
for ethanol reward, and states that elevated anxiety levels might predispose for ethanol …