Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Ecology of the respiratory tract microbiome

AE Pérez-Cobas, J Rodríguez-Beltrán, F Baquero… - Trends in …, 2023 - cell.com
A thriving multi-kingdom microbial ecosystem inhabits the respiratory tract: the respiratory
tract microbiome (RTM). In recent years, the contribution of the RTM to human health has …

A cross-systems primer for synthetic microbial communities

EC Mehlferber, G Arnault, B Joshi… - Nature …, 2024 - nature.com
The design and use of synthetic communities, or SynComs, is one of the most promising
strategies for disentangling the complex interactions within microbial communities, and …

Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics

S Hromada, OS Venturelli - Plos Biology, 2023 - journals.plos.org
In the human gut, the growth of the pathogen Clostridioides difficile is impacted by a
complex web of interspecies interactions with members of human gut microbiota. We …

Methods of quantifying interactions among populations using Lotka-Volterra models

JD Davis, DV Olivença, SP Brown… - Frontiers in Systems …, 2022 - frontiersin.org
The Lotka-Volterra (LV) model was introduced in the early 20th Century to describe predator-
prey systems. Since then, the model has been expanded to capture the dynamics of …

Mathematical models of cystic fibrosis as a systemic disease

DV Olivença, JD Davis, CM Kumbale… - WIREs Mechanisms …, 2023 - Wiley Online Library
Cystic fibrosis (CF) is widely known as a disease of the lung, even though it is in truth a
systemic disease, whose symptoms typically manifest in gastrointestinal dysfunction first. CF …

The impact of phage and phage resistance on microbial community dynamics

EO Alseth, R Custodio, SA Sundius, RA Kuske… - Plos …, 2024 - journals.plos.org
Where there are bacteria, there will be bacteriophages. These viruses are known to be
important players in shaping the wider microbial community in which they are embedded …

Disentangling direct vs indirect effects of microbiome manipulations in a habitat-forming marine holobiont

AH McGrath, K Lema, S Egan, G Wood… - npj Biofilms and …, 2024 - nature.com
Host-associated microbiota are critical for eukaryotic host functioning, to the extent that hosts
and their associated microbial communities are often considered “holobionts”. Most studies …

An eco-evolutionary perspective on antimicrobial resistance in the context of One Health

M Bustamante, S Mei, IM Daras, GS van Doorn… - iScience, 2025 - cell.com
Summary The One Health approach musters growing concerns about antimicrobial
resistance due to the increased use of antibiotics in healthcare and agriculture, with all of its …

Inference of dynamic interaction networks: A comparison between Lotka-Volterra and multivariate autoregressive models

DV Olivença, JD Davis, EO Voit - Frontiers in Bioinformatics, 2022 - frontiersin.org
Networks are ubiquitous throughout biology, spanning the entire range from molecules to
food webs and global environmental systems. Yet, despite substantial efforts by the scientific …