Ocular drug delivery barriers—role of nanocarriers in the treatment of anterior segment ocular diseases

RD Bachu, P Chowdhury, ZHF Al-Saedi, PK Karla… - Pharmaceutics, 2018 - mdpi.com
Ocular drug delivery is challenging due to the presence of anatomical and physiological
barriers. These barriers can affect drug entry into the eye following multiple routes of …

Cocrystal engineering of pharmaceutical solids: Therapeutic potential and challenges

SN Wong, YCS Chen, B Xuan, CC Sun, SF Chow - CrystEngComm, 2021 - pubs.rsc.org
Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Nanotechnology in ocular drug delivery

SK Sahoo, F Dilnawaz, S Krishnakumar - Drug discovery today, 2008 - Elsevier
Despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for
pharmaceutical scientists. Most ocular diseases are treated by topical drug application in the …

Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D, L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent …

T Niwa, H Takeuchi, T Hino, N Kunou… - Journal of controlled …, 1993 - Elsevier
Nanospheres with d, l-lactide/glycolide copolymer (PLGA) were prepared as a
biodegradable polymeric carrier for both water-soluble and insoluble drugs by a novel …

Microspheres for controlled release drug delivery

NK Varde, DW Pack - Expert opinion on biological therapy, 2004 - Taylor & Francis
Controlled release drug delivery employs drug-encapsulating devices from which
therapeutic agents may be released at controlled rates for long periods of time, ranging from …

Hollow microspheres for use as a floating controlled drug delivery system in the stomach

Y Kawashima, T Niwa, H Takeuchi, T Hino… - Journal of pharmaceutical …, 1992 - Elsevier
Hollow microspheres (microballoons), loaded with drug in their outer polymer shells, were
prepared by a novel emulsion–solvent diffusion method. The ethanokdichloromethane …

Eudragit RS100® nanosuspensions for the ophthalmic controlled delivery of ibuprofen

R Pignatello, C Bucolo, P Ferrara, A Maltese… - European journal of …, 2002 - Elsevier
Topical application of non-steroidal anti-inflammatory drugs on the eye is a common
treatment used to contrast the miosis induced by surgical traumas, such as cataract …

Preparation and characterization of poly (urea-formaldehyde) microcapsules filled with epoxy resins

L Yuan, G Liang, JQ Xie, L Li, J Guo - polymer, 2006 - Elsevier
The preparation of microcapsules applied to the fabrication of self-healing composites has
been paid more attentions. A new series of microcapsules were prepared by in situ …

Precise control of PLG microsphere size provides enhanced control of drug release rate

C Berkland, M King, A Cox, KK Kim, DW Pack - Journal of controlled release, 2002 - Elsevier
An important limitation in the development of biodegradable polymer microspheres for
controlled-release drug delivery applications has been the difficulty of specifically designing …

Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application

R Pignatello, C Bucolo, G Spedalieri, A Maltese… - Biomaterials, 2002 - Elsevier
Polymeric nanoparticle suspensions were prepared from Eudragit RS100® and RL100®
polymer resins and loaded with flurbiprofen (FLU), with the aim at improving the availability …