Quantitative preterm EEG analysis: the need for caution in using modern data science techniques

JM O'Toole, GB Boylan - Frontiers in pediatrics, 2019 - frontiersin.org
Hemodynamic changes during neonatal transition increase the vulnerability of the preterm
brain to injury. Real-time monitoring of brain function during this period would help identify …

Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

RK Jellema, V Lima Passos, A Zwanenburg… - Journal of …, 2013 - Springer
Background Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes of
brain injury in preterm infants. Preterm HIE is predominantly caused by global hypoxia …

Assessing instantaneous energy in the EEG: a non-negative, frequency-weighted energy operator

JM O'Toole, A Temko… - 2014 36th Annual …, 2014 - ieeexplore.ieee.org
Signal processing measures of instantaneous energy typically include only amplitude
information. But measures that include both amplitude and frequency do better at assessing …

Line length as a robust method to detect high-activity events: automated burst detection in premature EEG recordings

N Koolen, K Jansen, J Vervisch, V Matic… - Clinical …, 2014 - Elsevier
Objective EEG is a valuable tool for evaluation of brain maturation in preterm babies.
Preterm EEG constitutes of high voltage burst activities and more suppressed episodes …

DETECT: A MATLAB toolbox for event detection and identification in time series, with applications to artifact detection in EEG signals

V Lawhern, WD Hairston, K Robbins - PloS one, 2013 - journals.plos.org
Recent advances in sensor and recording technology have allowed scientists to acquire
very large time-series datasets. Researchers often analyze these datasets in the context of …

Functional connectivity in preterm infants derived from EEG coherence analysis

EJ Meijer, KHM Hermans, A Zwanenburg… - European journal of …, 2014 - Elsevier
Objective To quantify the neuronal connectivity in preterm infants between homologous
channels of both hemispheres. Methods EEG coherence analysis was performed on serial …

Sleep wake cycling in early preterm infants: comparison of polysomnographic recordings with a novel EEG-based index

K Palmu, T Kirjavainen, S Stjerna, T Salokivi… - Clinical …, 2013 - Elsevier
Objective To document the occurrence of genuine sleep stages in the early preterm babies,
and to develop an EEG-based index for following sleep wake cyclicity. Methods Twelve …

Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain

RK Jellema, DRMG Ophelders, A Zwanenburg… - Journal of …, 2015 - Springer
Background Preterm infants are at risk for hypoxic-ischemic encephalopathy. No therapy
exists to treat this brain injury and subsequent long-term sequelae. We have previously …

[HTML][HTML] Detecting bursts in the EEG of very and extremely premature infants using a multi-feature approach

JM O'Toole, GB Boylan, RO Lloyd, RM Goulding… - Medical Engineering & …, 2017 - Elsevier
Aim: To develop a method that segments preterm EEG into bursts and inter-bursts by
extracting and combining multiple EEG features. Methods: Two EEG experts annotated …

Holistic approach for automated background EEG assessment in asphyxiated full-term infants

V Matic, PJ Cherian, N Koolen… - Journal of neural …, 2014 - iopscience.iop.org
Objective. To develop an automated algorithm to quantify background EEG abnormalities in
full-term neonates with hypoxic ischemic encephalopathy. Approach. The algorithm …