FoxO (forkhead box O; forkhead members of the O class) are transcription factors that
function under the control of insulin/insulin-like signalling. FoxO factors have been …

Transplantation of amniotic membrane as a temporary or permanent graft promotes
epithelial wound healing and exerts potent anti-inflammatory and anti-scarring effects on the …

FoxO Forkhead transcription factors are shown here to act as signal transducers at the
confluence of Smad, PI3K, and FoxG1 pathways. Smad proteins activated by TGF-β form a …

Developing sympathetic neurons die by apoptosis when deprived of NGF. BIM, a BH3-only
member of the BCL-2 family, is induced after NGF withdrawal in these cells and contributes …

Paclitaxel is used to treat breast cancers, but the mechanisms by which it induces apoptosis
are poorly understood. Consequently, we have studied the role of the FoxO transcription …

When activated, the serine/threonine kinase AKT mediates an antiapoptotic signal
implicated in chemoresistance of various cancers. The mechanism (s) of AKT activation are …

Objective—Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor
that promotes endothelial cell (EC) survival, migration, and permeability. The forkhead …

Nerve growth factor (NGF) binding to p75 NTR influences TrkA signaling, yet the molecular
mechanism is unknown. We observe that NGF stimulates TrkA polyubiquitination, which was …

The type III transforming growth factor β (TGFβ) receptor (TβRIII) binds both TGFβ and
inhibin with high affinity and modulates the association of these ligands with their signaling …

Background Recent studies have shown that in the developing embryo, arterial and venous
identity is established by genetic mechanisms before circulation begins. Vascular …