T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

Chimeric antigen receptor (CAR) T cell therapy is revolutionizing cancer immunotherapy for
patients with B cell malignancies and is now being developed for solid tumors and chronic …

The antitumour activity of endogenous or adoptively transferred tumour-specific T cells is
highly dependent on their differentiation status. It is now apparent that less differentiated T …

Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous
surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and …

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved
treatment for hormone receptor–positive breast cancer and are currently under evaluation …

An increasing body of evidence emphasizes the role of tissue-resident memory T cells (T
RM) in the defense against recurring pathogens and malignant neoplasms. However, little is …

CD8+ T cells are the key executioners of the adaptive immune arm, which mediates
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …

c-Jun is a major component of the dimeric transcription factor activator protein-1 (AP-1), a
paradigm for transcriptional response to extracellular signaling, whose components are …

Recent studies have characterized populations of memory CD8+ T cells that do not
recirculate through the blood but are, instead, retained in nonlymphoid tissues. Such CD8+ …