Efforts are being made worldwide to understand the immune response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus …

Bruton tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a major therapeutic target for
B-cell–driven malignancies. However, approved covalent BTK inhibitors (cBTKis) are …

Internal modification of RNAs with N 6-methyladenosine (m 6 A) is a highly conserved
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …

Many individuals mount nearly identical antibody responses to SARS-CoV-2. To gain insight
into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response …

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading
target for next-generation vaccines against the disease-causing blood-stage of malaria …

Sexual reproduction is almost universal in eukaryotic life and involves the fusion of male and
female haploid gametes into a diploid cell. The sperm-restricted single-pass transmembrane …

Designing covalent inhibitors is increasingly important, although it remains challenging.
Here, we present covalentizer, a computational pipeline for identifying irreversible inhibitors …

During cell migration or differentiation, cell surface receptors are simultaneously exposed to
different ligands. However, it is often unclear how these extracellular signals are integrated …

Summary RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic processes and
have been implicated in numerous diseases, but targeting these enzymes remains a major …

To combat the emergence of drug-resistant strains of Mycobacterium tuberculosis, new
antitubercular agents and novel drug targets are needed. Phenotypic screening of a library …