Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Fibrotic diseases are a significant global burden for which there are limited treatment
options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly …

In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed
to occur because of a persistent tissue repair program. During connective tissue …

Cardiac fibrosis is a substantial problem in managing multiple forms of heart disease.
Fibrosis results from an unrestrained tissue repair process orchestrated predominantly by …

After SARS-CoV-2 infection, a major complication of those who survived to COVID-19
outbreak is the development of severe lung disease leading to pulmonary fibrosis. At earliest …

Organ fibrosis is a pathological condition associated with chronic inflammatory diseases. In
fibrosis, excessive deposition of extracellular matrix (ECM) severely impairs tissue …

Highly active antiretroviral therapy (HAART) can suppress HIV-1 replication and normalize
the chronic immune activation associated with infection, but restoration of naïve CD4+ T cell …