Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Coenzyme Q (CoQ) is present in all cells and membranes and in addition to be a member of
the mitochondrial respiratory chain it has also several other functions of great importance for …

HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …

The effects of chronic sun exposure on skin are readily apparent when skin not typically
exposed to the sun and skin regularly exposed to the sun are compared. While the sun is not …

Great progress has been made toward understanding the pathogenesis of Parkinson's
disease (PD) during the past two decades, mainly as a consequence of the discovery of …

In addition to its role as a component of the mitochondrial respiratory chain and our only lipid-
soluble antioxidant synthesized endogenously, in recent years coenzyme Q (CoQ) has been …

Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal
ganglion cells and their axons. Lowering of intraocular pressure (IOP) is currently the only …

Oxygen metabolism in the mitochondria is essential for biological activity, and reactive
oxygen species (ROS) are produced simultaneously in the cell. Once an imbalance between …

A large body of evidence from postmortem brain tissue and genetic analysis in humans and
biochemical and pathological studies in animal models (transgenic and toxin) of …