Perspectives on precision cut lung slices—powerful tools for investigation of mechanisms and therapeutic targets in lung diseases
Precision cut lung slices (PCLS) have emerged as powerful experimental tools for
respiratory research. Pioneering studies using mouse PCLS to visualize intrapulmonary …
respiratory research. Pioneering studies using mouse PCLS to visualize intrapulmonary …
Regulation of airway smooth muscle contraction in health and disease
Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the
terminal bronchioles. In utero, spontaneous phasic contraction of fetal ASM is critical for …
terminal bronchioles. In utero, spontaneous phasic contraction of fetal ASM is critical for …
Critical role for iron accumulation in the pathogenesis of fibrotic lung disease
Increased iron levels and dysregulated iron homeostasis, or both, occur in several lung
diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis …
diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis …
Advances in respiratory physiology in mouse models of experimental asthma
Recent advances in mouse models of experimental asthma coupled with vast improvements
in systems that assess respiratory physiology have considerably increased the accuracy and …
in systems that assess respiratory physiology have considerably increased the accuracy and …
Third-hand exposure to e-cigarette vapour induces pulmonary effects in mice
In the last decade, e-cigarette usage has increased, with an estimated 82 million e-cigarette
users globally. This is, in part, due to the common opinion that they are “healthier” than …
users globally. This is, in part, due to the common opinion that they are “healthier” than …
[HTML][HTML] Cholinergic neuroplasticity in asthma driven by TrkB signaling
G Dragunas, ME Woest, S Nijboer, ST Bos… - The FASEB …, 2020 - ncbi.nlm.nih.gov
Parasympathetic neurons in the airways control bronchomotor tone. Increased activity of
cholinergic neurons are mediators of airway hyperresponsiveness (AHR) in asthma …
cholinergic neurons are mediators of airway hyperresponsiveness (AHR) in asthma …
Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices
The direct relationship between pulmonary structural changes and airway
hyperresponsiveness (AHR) in chronic obstructive pulmonary disease (COPD) is unclear …
hyperresponsiveness (AHR) in chronic obstructive pulmonary disease (COPD) is unclear …
Airway remodeling and hyperreactivity in a model of bronchopulmonary dysplasia and their modulation by IL-1 receptor antagonist
Bronchopulmonary dysplasia (BPD) is a chronic disease of extreme prematurity that has
serious long-term consequences including increased asthma risk. We earlier identified IL-1 …
serious long-term consequences including increased asthma risk. We earlier identified IL-1 …
Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms
Sulforaphane has been investigated in human pathologies and preclinical models of airway
diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the …
diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the …
Assessment of airway response distribution and paradoxical airway dilation in mice during methacholine challenge
Detailed information on the distribution of airway diameters during bronchoconstriction in
situ is required to understand the regional response of the lungs. Imaging studies using …
situ is required to understand the regional response of the lungs. Imaging studies using …